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doi: 10.1038/cmi.2017.88 230 MacMickingJD

This protocol results in eccentric muscle damage to exacerbate the mdx mouse skeletal muscle phenotype

Results: In the CCl 4 mouse model of HE and in human autopsy samples, markers of senescence and SASPs were observed, specifically in neurons of the CA1 and dentate gyrus in the hippocampus and in the Purkinje cell layer in the cerebellum, regions known for learning, memory and motor control