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This cascade leads to neuronal apoptosis and energy deficits, particularly in the prefrontal cortex and hippocampus ( 4.3 Excitotoxicity Synthetic cathinones disrupt glutamatergic signaling by enhancing glutamate release and impairing astrocytic uptake (Zhang and Bhavnani, 2006)

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This schedule is consistent across all months of the cycle

Analogously, low concentrations of the cortisol interfere negatively in the expression of BDNF