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OReilly S, Hgle T, van Laar JM (2012) T cells in systemic sclerosis: a reappraisal

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In part B of the study, which was open label, patients were assigned to receive a single IV infusion of pegadricase alone (0.4 mg/kg) alone, or SEL-212 (0.03, 0.1, 0.15, or 0.3 mg/kg ImmTOR combined with 0.4 mg/kg pegadricase

The corresponding protein is defective in DNA-binding because the insertion has occurred between the first and second zinc cluster