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It is therefore tempting to speculate that branched ubiquitin chains reprogram p97 to cooperate with ATXN3 on damaged lysosomes and facilitate degradation of proteins such as LAMP2 in the lysosome via microautophagy

This is important in neurodegenerative diseases.[ref] Related article: TNF-alpha: Inflammation, Chronic Diseases, and Genetic Susceptibility RAGEs and Glyoxalase-1 interact: As I talked about above, the enzyme glyoxalase breaks down one of the precursors for AGEs (methylglyoxal)

Aminosalicylic acid and colchicine can interfere with B12 handling

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