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Several studies have proved the clinical efficacy of Doxil, where improved tumor response rates and a favorable safety profile were observed compared to the conventional formulation of doxorubicin

J Proteome Res 15:31083117 Leonard MM, Bai Y, Serena G, Nickerson KP, Camhi S, Sturgeon C, Yan S, Fiorentino MR, Katz A, Nath B et al (2019) RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis

Alpha-Synuclein Contribution to Neuronal and Glial Damage in Parkinsons Disease

For the quantification of sulfur metabolites in the tissue samples, the tissue metabolites were extracted and derivatized with NEM in ice-cold extraction solvent (80% MeOH: 20% H 2 O containing 25 mM NEM and 10 mM ammonium formate, pH=7.0) which includes stable isotope labeled internal standards (20 M [ 13 C 3 , 15 N]-cysteine-NEM, 36.4 M [ 13 C 2 , 15 N]-GSH-NEM, 10 M [D 4 ]-Cystine, 0.92 M [ 13 C 5 , 15 N 2 ]-GSSG, 20 M [D 4 ]-Hypotaurine, and 20 M of [ 13 C 2 ]-Taurine at a final concentration of 50 mg/mL followed by incubation on 4 C for 24 hr

Stress stimuli and altered cellular metabolism might trigger an increase in ROS production and a depletion of antioxidant defense systems, resulting in a defective mitochondrial respiratory chain, mutation in mtDNA, and altered Ca 2+ homeostasis