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Methods Ethics statement All experimental procedures involving mice were reviewed and approved by the Columbia University Institutional Animal Care and Use Committee (IACUC)

Of note, our tracing data also suggest that a peroxisomal route is likely important for at least a portion of fatty acid-dependent acetyl-CoA production

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Studies examining the timing of combined administration have consistently shown that simultaneous or near-simultaneous administration produces maximal synergy, with the synergistic component declining as the interval between administrations increases beyond 15-30 minutes

Zhang R, Zhang Y, Wang Y et al (2019a) Pregnenolone overproduction in Yarrowia lipolytica by integrative components pairing of the cytochrome p450scc system