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For instance, it was shown that repeated light-dark shifts in male C57BL/6 mice exacerbated colonic inflammation and tissue damage, pointing to heightened systemic inflammatory responses 125

GSH AND OXIDATIVE STRESS The investigation on the field related to production of ROS/RNS during metabolic processes, even under physiological conditions, unlocks another branch of research focusing on the role of GSH ranging from antioxidant/radical scavenger to redox signaling modulator

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5 Clinical implications of Met-based combination therapies The combination therapies of Met explored for PCOS management demonstrate promising multimodal benefits, particularly in improving IR, reducing inflammation, and ameliorating hormonal dysregulation ( Table 3 )

doi: 10.1007/s00262-018-2185-1 [DOI] [PMC free article] [PubMed] [Google Scholar] 32.Paul BD, Sbodio JI, Snyder SH