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This makes it a useful system for studying receptor-driven endocrine responses

Soluble oligomers of amyloid- cause changes in redox state, DNA methylation, and gene transcription by inhibiting EAAT3 mediated cysteine uptake

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Mol Cell Biol 23 : 67396749 Collard KJ, Godeck S, Holley JE, Quinn MW 2004 Pulmonary antioxidant concentrations and oxidative damage in ventilated premature babies

Increased insulin-like growth factor-1 activity has been reported in cases of polycystic kidney disease, while IGF-1 resistance where the body produces enough of this polypeptide but is unable to metabolize or use it is seen in many cases of chronic kidney failure