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Description

In conclusion, the occurrence of DFU is closely related to cell dysfunction, low-grade inflammation, and tissue hypoxia induced by hyperglycemia

Glucose-6-phosphate will metabolically trifurcate into the following pathways: (i) conversion to fructose-6-phosphate by the enzyme phosphoglucose isomerase, entering the glycolytic pathway, or (ii) oxidation by glucose-6-phosphate dehydrogenase to 6-phosphogluconolactone, thereby initiating the oxidative phase of the pentose phosphate pathway