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For patients and caregivers navigating these invisible illnesses, the search for validating answers and effective management strategies can feel incredibly overwhelming

Besides, the protruding nucleus pulposus ruptures the blood-disk barrier, which liberates ROS and inflammatory factors causing an autoimmune response that intensifies the pain [24, 96]

The volcano plot displayed the up- and downregulated differential genes in each dataset (Fig

Moreover, PAI-1 mediates fibrosis of various organs including the heart 55 , lungs 56 , and kidneys 57 , and increases the pathogenesis of coronary artery disease 58 , atherosclerosis 59 , diabetes 54 , and cancer 60,61

All MS data can be found in Supplementary Table 2