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The materials used in modern fillings have largely been proven to be safe, and much safer than that of amalgam

Randomization was carried out using a minimization approach [Pocock and Simon (1975)] using the following factors: gender, ECOG PS (0 versus 1), response to prior chemotherapy (complete or partial response versus stable disease), history of brain metastases (yes versus no), non-platinum component of induction therapy (docetaxel versus gemcitabine versus paclitaxel), and disease stage (IIIb versus IV)

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Bacteriostatic water contains a preservative intended to inhibit microbial growth during repeated vial access, while sterile water for injection typically contains no additives and is often referenced for single-use preparation