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These medications are administered via subcutaneous injection, typically weekly (semaglutide) or daily (liraglutide)

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P53, a tumor suppressor protein, is a critical regulator in various cell biological processes, mainly including cell cycle arrest and apoptosis, which is closely associated with AKI progression (Tang et al., 2019)

With respect to neurotrophic signaling and neuroplasticity, all three agents enhance brain-derived neurotrophic factor (BDNF)-related pathways, but through distinct biological routes

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