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Despite these constraints, the present review provides a timely, integrated synthesis of current and emerging therapeutic strategies, contextualized with the latest clinical and translational developments through early 2025

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Unlike outer-sphere electron transfer, the reaction between transition metals and H 2 O 2 occurs via an inner-sphere mechanism, forming a complex before electron transfer (Goldstein et al

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doi: 10.1126/science.aaf6284 65 Souto-CarneiroMMKlikaKDAbreuMTMeyerAPSaffrichRSandhoffRet al