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Subsequently, this impairs IDH1-dependent reductive carboxylation, a tumor cell requirement limited to 3D growth, inducing a decrease in intramitochondrial NADPH, an increase in ROS, and finally mitochondrial supercomplexes assembly disruption, which ultimately impairs cell transformation and tumorigenesis

Adjacent human efficacy in non-growth indications Borasio et al

This is when you get out of sync with your circadian rhythm, which is your roughly 24-hour body clock

Only if we show that an improvement in functioning reflects memory as such, and not a change in mood, arousal, attention, executive functioning or anything else, will we have established that an intervention has influenced disease progression