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By contrast, the k cat values of the ketosteroid isomerase activity of human, equine, and marmoset GST A3-3 are two orders of magnitude higher, ranging between 204 and 261 s 1 ( Our enzymological studies have established 5-PD and 5-AD as outstanding substrates for the equine and human GST A3-3 enzymes, and we predict that the corresponding 3-keto intermediates derived by oxidation of the 3-hydroxy groups of 17-hydroxypregnenolone and androstenediol will also be substrates, although they have not yet been tested

The liver, kidney, testes, heart, pancreas, and smooth muscle all have high levels of PPAR- isoform expression

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The -Gal A KO mouse model, the first in vivo model of Fabry disease, showed a marked increase in Gb3 in the kidneys 34