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Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

Sources: Busebee, Bradley, et al

Treatments for Parkinson diseasepast achievements and current clinical needs

Based on these findings, it is hypothesized that IL-17A inhibitors may improve intestinal inflammation in PSO patients by increasing the abundance of Eubacterium_hallii_group , which promotes SCFA production while increased Parasutterella promotes hypoxanthine production and regulates BAs metabolism in patients, which in turn improves intestinal barrier function and achieves the relief of clinical symptoms

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