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Intrinsic biochemical differences between the hepatocytes of the various species have been also reported

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As an innovative drug delivery strategy, transdermal administration of plant bioactive metabolites, which delivers active metabolites to the body or local target tissues via the dermal route, retains the natural advantages of plant bioactive metabolites while overcoming their inherent limitations through dosage form design

Second, as an observational study, causality cannot be established, and the findings remain susceptible to residual confounding from unmeasured factors, including confounding by indication, disease severity, prescribing preferences, and lifestyle factors such as diet, physical activity, or cognitive engagement

A major advance would be the ability to fabricate compartments ex vivo and deliver them into cells to stably function as designer synthetic hubs or organelles