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Gut dysbiosis, characterized by microbial composition and function alterations, contributes to systemic inflammation and metabolic imbalances, exacerbating CKD progression

This can sometimes lead us to a genetic mutation called methyl-tetrahydrofolate reductase, or MTHFR

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These grading scales include the Ajani Sensory, Eastern Cooperative Oncology Group (ECOG), National Cancer InstituteCommon Terminology Criteria for Adverse Events (NCICTCAE), and World Health Organization (WHO) systems, which grade CIPN severity on a scale of 0 (normal) to 5 (death)

The tissues were then centrifuged at 5000 rpm for 5 minutes to collect the supernatant in Eppendorf tubes, and stored at -20 C for biochemical tests