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Choice of NNRTI Doravirine and rilpivirine are the NNRTI anchor drugs available in the category of Other Initial Antiretroviral Regimens for Certain Clinical Scenarios .[69] Rilpivirine should not be used in persons who have a current HIV RNA level greater than or equal to 100,000 copies/mL or a current CD4 count less than or equal to 200 cells/mm 3 .[69,73] In addition, rilpivirine is contraindicated for individuals who are taking a proton pump inhibitor, and it must be taken with food.[69] Doravirine is well tolerated, can be taken with or without food, and can be used in combination with proton pump inhibitors