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1528-P: hypothalamic SEL1L-HRD1 ER-associated degradation is indispensable for leptin signaling in diet-induced obesity by degrading misfolded leptin receptor

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Long-term risks (over 6 months excessive use): microinflammation in renal tubules, increased uric acid, and disturbed methylation balance (SAM/SAH ratio) due to excess creatine recycling

The primary outcome worsened by 3.5 points in the placebo group and 6.0 points in the nicotine group

Dosage reduction and/or discontinuation of amlodipine and valsartan may be required [see Adverse Reactions (6.1)]