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Metabolic impairments like decreased respiratory exchange rates were also found in the SPRDtgHD rat model from an early age 57

[23] The Werner (WRN) DNA helicase gene, which controls the transcription of the crucial NAD+ biosynthetic enzyme nicotinamide nucleotide adenylyltransferase 1, is the source of WS

These approaches are subject to many of the same limitations as nutritional/microbiota therapies for TBI, including the lack of a suitable animal model of the human microbiome, heterogeneity in the methods/quality of microbiome data collection, the protracted timeline and inevitable presence of confounding variables in human diet trials [130]

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Foods high in vitamin C include: Citrus fruits like oranges, lemons, and grapefruits Strawberries Bell peppers Research highlights that vitamin C supplementation can prevent glutathione depletion during periods of oxidative stress