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After inspection of the apo-OsDHAR structure, we predicted that the highly conserved Cys20 residue acts as the catalytic nucleophile and found that this residue is located at the cleft between the N- and C-terminal subdomains

Main First identified by Albert Claude in 1945 1 , the endoplasmic reticulum (ER) was later defined by George Palade through electron microscopy as a highly specialized membrane-bound organelle essential for the synthesis, folding, and maturation of secretory and membrane proteins 2

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PMCID: PMC5274660

Stimulates cellular renewal, encouraging the elimination of melanin and migrating it towards the stratum corneum