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This metabolic shift toward glycolysis impaired NAD+ redox balance and increased protein acetylation, including that of SERCA2a, leading to contractile dysfunction

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Participants were only included if they met a stringent set of criteria: a strength-training history of at least three years absence of chronic medical conditions non-smokers non-drinkers of alcohol ability to train at least three days per week Participants must not have a history as professional athletes or have used ergogenic aids to enhance performance, such as creatine, omega-3 supplements, protein powders, or branched-chain amino acids (BCAAs), within six months of the trial

10.3389/fphar.2022.844756 91 KlionskyD