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Simon, A., Cobbold, S

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One Protein, Multiple Phenotypes: A Concept of Neuronal Vulnerability Aside from mitochondrial dysfunction, misfolded SOD1 is implicated in the initiation and/or acceleration of numerous damaging pathways in both neurons[ 13 , 59 , 207 ] and surrounding glia, [208] including disruption of proteasome function, degradation of microtubules and microfilaments, endoplasmic reticulum stress, and redox dyshomeostasis