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A predictive eco-metabolomic framework for AQflavonoid systems should combine (i) multifactorial experimental designs that manipulate at least two interacting abiotic drivers, (ii) high-resolution metabolomic profiling across tissues and developmental stages, and (iii) integrative analytical approaches linking metabolite data to physiological performance and fitness proxies

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Current pharmacological approaches do not have a sound rationale, and there is a strong medical demand for novel therapeutic regimens

2019;6:ENEURO.026719.2019

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