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Epigenetic regulators have gained considerable attention as their expression is deregulated in several cancers [7]

T lymphocytespecific activation of Nrf2 protects from AKI

Furthermore, the relationship between the gut-brain axis and mitochondrial dysfunction has gained attention because changes in the gut microbiota may affect mitochondrial health and contribute to systemic inflammation, which in turn exacerbates neuropathic pain [72, 73]

In summary, normal Nrf2 function protects cells from oxidative stress and inflammatory damage by increasing antioxidant defences, thereby contributing to cellular protection and the regulation of immune responses

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