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One mechanism by which adipocytes promote resistance is through pyroptosis-induced lipid release, wherein dying adipocytes liberate free fatty acids that are then taken up by adjacent tumor cells and provide a metabolic substrate that supports survival and reduces platinum sensitivity [138]

Heavy drinkers with depressive symptoms typically exhibit (1) later age of MDD onset (post-25 years), (2) predominance of somatic symptoms (e.g., fatigue, insomnia) over cognitive rumination, and (3) partial responsiveness to selective serotonin reuptake inhibitors (SSRIs), which may reflect underlying serotonergic deficits compounded by ethanols neurotoxic effects (Pedrelli et al

Several gene expression patterns were discovered in our analyses

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