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Under sub-optimal conditions warm ambient temperatures, frequent puncture without consistent aseptic technique, light exposure the effective preservation window may shorten to less than 28 days even though the calendar window has not elapsed

We demonstrated therapeutic protection of photoreceptor structure and function in a chemically-induced rat model of RP (48% increase in photopic b-wave amplitude), as well as some limited protection in an aggressive genetic mouse model ( rd10 ) of retinal degeneration (~ 31% increase in photopic b-wave amplitude) with once daily application