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The Shoemaker Protocol is officially part of the Bredesen Protocol as is key in establishing the level of neurologic harm associated with biotoxins

The primary pathways for clearing L-OOHs in ferroptosis are the cystine/glutamate antiporter system-glutathione-glutathione peroxidase 4 axis (System Xc-/GSH/GPX4 axis), the ferroptosis suppressor protein 1-coenzyme Q10-nicotinamide adenine dinucleotide phosphate axis (FSP1/CoQ10/NADPH axis), and the GTP cyclohydrolase 1-tetrahydrobiopterin-dihydrofolate reductase axis (GCH1/BH4/DHFR axis) (Figure 1C)

Anjo SI, Melo MN, Loureiro LR et al (2019) OxSWATH: an integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening

if the regimen cannot be changed, transfusions are necessary

Brain Health: Influences neurotrophic pathways such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) , which are involved in neuron survival and plasticity