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While our data suggest that production of NADPH by the TCA cycle is a key event in our proposed pathway, it is not yet clear how NADPH production corresponds to actual activity of the cyclegiven that metabolites can enter and exit the cycle at multiple points depending on nutritional conditionsnor how the cellular compartmentalization of NADPH production contributes to the transmission of the NADPH status to the ER

Our LC-MS and GC-MS platforms are optimized for both targeted quantification of known organic acids and untargeted screening for novel or unexpected metabolites

PLoS neglected tropical diseases 10, e0004383

Biochem Pharmacol 34(14):25832586 Hartmann JT, Lipp HP (2003) Toxicity of platinum compounds

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