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Hypoxia-inducible factor 1alpha activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver

IGF-1 in the CNS IGF-1 can cross the blood brain barrier (BBB) and enter CSF, and perform a number of important functions of the CNS, including neurogenesis and neuroprotection, through autocrine/paracrine or endocrine effects

These micro-clots, which trap inflammatory molecules and prevent proper oxygen exchange in microcapillaries, may contribute to fatigue and other symptoms seen in Long COVID (Baker et al., 2022)

Psychiatric symptoms like depression can become severe, and swallowing difficulties will increase the risk of choking and aspiration pneumonia, which is a common cause of death

GLP-1Rpositive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in mice