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Influenza a virus replication is dependent on an antioxidant pathway that involves GSH and Bcl-2

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After tissue distribution, AITC is conjugated to glutathione in the liver and excreted in the urine as mercapturic acid (AITC-NAC), which accounts for a 50-80% dose of ingestion ITC [27-29]

Model curation provides researchers with the ability to obtain, adapt and implement such mathematical models, as outlined in this study, and is therefore a powerful tool in the arsenal of any systems biologist, pharmacologist or toxicologist

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