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Unsafe doses are much larger than those discovered in these studies

doi: 10.3389/fnut.2019.00048 81 ChenACMartinAJChoyBFernndez-PeasPDalziellRAMcKenzieCAet al

This study is part of the doctoral thesis of David Barinberg to obtain a Dr

Conversely, therapeutic improvement of SOD1 copper metallation has also shown the ability to significantly improve phenotype and survival of mutant SOD1 mice 63,101,102 and could be applicable to the human sporadic form of ALS which shows evidence of copper dysregulation unrelated to SOD1 mutations 15