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308 Overactivation of NMDARs by A leads to abnormal calcium influx, triggering a cascade of downstream signaling events, resulting in dendritic spine loss, reduced distribution of NMDARs on neuronal membranes, impaired synaptic plasticity, and ultimately, cognitive decline

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All animal procedures adhered to the guidelines for the care and use of laboratory animals at Nankai University and were approved by its Ethics Review Committee (ethics approval no