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b , NMuMG cells after expression of FGFR218 mutant 43

An unbiased genome-wide siRNA screen for suppressors of ferroptosis found that loss of cysteinyl-tRNA synthetase (CARS) increases cystathionine and activates the transsulfuration pathway to suppress ferroptosis, which is induced by the well-known system ( SLC7A11 ) inhibitor, erastin (Table 1) (Hayano et al., 2016)