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Chiarelli PG, Suh JH, Pegg RB, Chen J, Mis SK

Bacteria-derived natural products are mainly tested in their extract form or pure form

LuoM-LZhengFChenWLiangZ-MChandramoulyGTanJet al

Fe(III)-shikonin supramolecular nano-medicine for combined therapy of tumor via ferroptosis and ne-croptosis

More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]