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Affinity for the unphosphorylated peptide was strongly reduced ( K d = 81.0 4.5 M), while mutation of the conserved R3552 to alanine abrogated the binding to both peptides (Fig

The regulator is also not requesting that AbbVie conduct additional efficacy and safety trials related to the drug or device-related testing

Because of that, it is important to be precise

It should be noted, however, that while retatrutide shows promise as a weight-loss therapy for adults, its use is not currently approved for children and adolescents