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Its prevalence is increasing markedly worldwide due to ageing populations and a lack of disease modifying therapies

The thiols cysteine and GSH are involved in the redox process through a disulfide conversion system that leads to the homeostasis of oxidative stress in plants [13]

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Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide

Since GSTO1 has been known to cause de-glutathionylation of -actin impeding its polymerization into filamentous actin 11 , such a downregulation of molecules involved in cytoskeleton organization and adhesion is particularly interesting