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HeYQDengJLZhouCCJiangSGZhangFTaoXet al

Bioavailability of sublingual route is better and this route requires lower doses and has been considered to be safe by Food and Drug Administration (FDA)

10.1016/j.freeradbiomed.2018.09.033 90 MiottoG.RossettoM.Di PaoloM

Differences in survival were determined by Log-rank (Mantel-Cox) test using the GraphPad Prism v7.0 (GraphPad, La Jolla, CA) software

The result is a synergistic pulse that is significantly larger than either peptide alone, while still being a physiological pulse rather than a pharmacological spike