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Baseline labs (with IGF-1 for growth hormone peptides) and periodic re-checks are how a clinician doses safely and tracks whether a protocol is working

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This selectivity was demonstrated in the landmark study by Raun et al.: at doses producing a maximum increase in GH, ipamorelin did not alter plasma cortisol or prolactin levels (Raun et al., Eur J Endocrinol 1998)