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Cells 9 (8), 1861

doi: 10.1126/scisignal.abe3800 59 LuCYangDKlementJDColsonYLOberliesNHPearceCJet al

Manipulating the expression level of the astrocyte-specific plasma membranemicrofilament linker ezrin alters resilience to stress 147

CP deficiency disrupts this process, leading to pathological Fe 2+ accumulation and subsequent ferroptosis induction ( 4.2.2 System Xc System Xc , a critical intracellular antioxidant component, is an amino acid antiporter composed of the light chain SLC7A11 (xCT) and heavy chain SLC3A2 (4F2hc), which are interconnected by disulfide bonds (Zhang G

These results were contributed to drawing the conclusion that EPS could decrease cellular oxidative stress and restore mitochondrial function, thereby exerting a powerful antioxidant effect to resist cell damage