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found that H/R led to apoptosis of H9c2 cells while increasing the expression levels of cGAS, STING, and cleaved caspase3 and decreasing the Bcl2/Bax ratio

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In fact, studies show that 85% of patients on 0.5 1.0 mg/kg/day achieve clear skin within 16 weeks, while 13% need 56 months of treatment and less than 1% may need to take the medication for up to 12 months 17