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Tryptophan can be converted to indole-3-pyruvate (I3P) by interleukin-4-induced-1 (IL4i1), which protects cancer cells from ferroptosis through scavenging lipophilic radicals, increasing the GSH/ Glutathione disulfide (GSSG) ratio, upregulating the expression of SLC7A11 and targeting some genes in the antioxidant signaling pathway, such as hemeoxygenase-1 (HO-1) [87]

doi: 10.1155/2014/426951 118 RossCMorrissAKhairyMKhalafYBraudePCoomarasamyAet al

BMJ 313, 14171418

598p.10.1002/9780470475973 Glutathione and Sulfur Amino Acids in Human Health and Disease

The result is diminished membrane elasticity with consequent membrane destabilization, erythrocyte fragmentation and elongation (elliptocytosis), and increased osmotic fragility