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Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis

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Static compression significantly inhibits the viability, migration, clonogenicity, and multidifferentiation potential of NP-MSCs and reduces their stemness, suggesting it may play an important role in hindering endogenous disc repair ( Furthermore, the physical properties of the substrate (such as stiffness and fiber alignment) also significantly regulate stem cell differentiation

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[1] That program is complete, but a completed Phase 3 program is not an approval and that gap is where most of the confusion in this comparison lives

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