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Combination treatment options targeting ferroptosis in LC Reversing chemotherapy resistance The persistent challenge of drug resistance is a notable obstacle in cancer therapy, particularly with treatments such as platinum-based chemotherapy for LC

VMAT2 exploits this H gradient via protonmonoamine exchange to actively transport cytosolic monoamines into the vesicle against their concentration gradient, enabling vesicular storage and subsequent regulated neurotransmitter release

Cells were collected 48 h after transfection for analysis of apoptosis, stained with FITC Annexin V Apoptosis Detection Kit I ( BD biosciences, USA), and analyzed by flow cytometry

Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

These impairments drive autophagic and endosomal abnormalities