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Description

Nature 569 , 723728 (2019)

Full receptor profile: High affinity (Ki 90% of H1 antihistamine receptors at peak serum levels, so its conceivable that peak sedating effects from quetiapine could occur in a relatively low dosing range (e.g., ~50-100 mg)

History First synthesized in the early 1990s by researchers investigating cytoprotective proteins found in gastric juice

The glutamate produced during the glutamine metabolism is further converted into -ketoglutarate (-KG) through glutamate dehydrogenase 1 (GLUD1), transaminases such as glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), and phosphoserine transaminase (PSAT) and subsequently participates in the TCA cycle