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In this compound, penicillamine replaces the cysteine moiety of CAO

Clinically, anticholinergic drugs are often used in combination with L-DOPA or dopamine receptor agonists, primarily for the treatment of PD patients with tremor [132]

In patients with ME/CFS and Long COVID, advanced neuroimaging studies have consistently demonstrated abnormally low levels of brain glutathione coupled with highly elevated levels of ventricular lactate, a clear indicator of neuroinflammation and mitochondrial distress

Therefore, it can have a toxic effect on -synuclein fibrillation by increasing the number of oligomeric species and protofibrils rather than full length fibrils (Kumari et al., 2022)

Under normal physiological conditions, NRF2 binds to Kelch-like ECH associated protein 1 (KEAP1) and is inactivated through proteasome-mediated ubiquitination degradation