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Chemical Reviews, 120(12), 49214968

Key Nutrients Depleted by Corticosteroids Corticosteroids are associated with depletion of multiple nutrients essential for tissue repair, immune defense, and metabolic stability, including: Calcium, vitamin D, magnesium, potassium, zinc, selenium, vitamin C, and protein (1) Mechanisms of Steroid-Induced Nutrient Depletion Calcium & vitamin D: Reduced intestinal absorption and increased urinary loss osteopenia and fracture risk Zinc, selenium & vitamin C: Impaired immune function, delayed wound healing, increased infection risk Protein: Accelerated protein breakdown muscle wasting and connective tissue weakness Magnesium & potassium: Electrolyte imbalance fatigue, weakness, and cardiac rhythm disturbances Why Steroid-Induced Nutrient Depletion Impairs Healing By chronically elevating cortisol signaling, corticosteroids shift the body into a catabolic, stress-dominant state

This effect was accompanied by increased expression of melanocortin receptor type 2 (MC2R) and steroidogenic acute regulatory protein (StAR) in the adrenal glands, alongside decreased glucocorticoid (GR) and mineralocorticoid (MR) receptor expression in the pituitary

Dividing this into the total value of the major contracts from Table 3 of $5,099,000 gives an average cost of $4,453 for each truck Oshkosh produced during World War Two