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Folate and vitamin B12: friendly or enemy nutrients for the elderly

The findings with depleted amino acids in the plasma of patients with thyroid nodules may exhibit excessive consumption of the amino acids by the tumor cells to sustain cell proliferation

where the product(s) of this reaction are denoted as Compound II

Based on the cyclobutenedione structure, acidic hydroxyl groups are replaced by superior leaving groups and then various nucleophiles can react at the carbonyl or olefinic carbon centres