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This study investigated the effects of metformin and chloroquine on the efficacy of cytarabine in NALM-6 cells

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In brain tissue, misfolded proteins such as amyloid-beta and tau can sequester copper ions, creating local copper deficiency while simultaneously generating reactive oxygen species through aberrant metal-protein interactions

Finally, by analyzing the translational gap between conventional and emerging approaches, the imperative for precision, mechanism-oriented individualized therapy is emphasized, thereby providing a comprehensive reference for both fundamental research and clinical practice in the field

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells